Mammalian cellular processes attributed to I3C action are as diverse as the different phenotypes presented by the many cancers studied. The F-box protein TIR1 is an auxin receptor. Sixty women at increased risk for breast cancer were enrolled in a placebo-controlled, double-blind dose-ranging chemoprevention study of indolecarbinol I3C. Cancer Epidemiol Biomarkers Prev. These two I3C-dependent processes were detected in roots not only after direct exposure to exogenously applied I3C but also following the treatment of leaves with I3C.
Dose-ranging study of indole-3-carbinol for breast cancer prevention.
Molecular mechanisms of steroid hormone signaling in plants. J Sci Food Agric. Myrosinase-catalyzed breakdown of I3M-GS leads to the formation of unstable intermediates and then to indoleacetonitrile I3N and indolecarbionol I3C. This conclusion is supported by transcript-profiling results showing the downregulation of cell cycle genes six hours following exposure to I3C Direct inhibition of elastase activity by indolecarbinol triggers a CDTRAF regulatory cascade that disrupts NF-kappaB transcriptional activity in human breast cancer cells.
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Proc Soc Exp Biol Med. The referees who approved this article are: Beneficial and adverse effects of chemopreventive agents. Autophagy in Plants--What's New on the Menu? I3C affects plant growth and development by directly modulating auxin signaling.
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